Abstract： Objective To summarize the characteristics of use of fresh medicine in Qixiao Liangfang,and provide reference for the clinical application and research of fresh medicine.Methods We searched fresh Chinese herbal medicines in Qixiao Liangfang,established a database with Excel 2016 for data mining.The characteristics of fresh Chinese herbal medicines in Qixiao Liangfang were analyzed,including frequency,taste,meridian distribution,and toxicity.Results Totally 246 fresh Chinese herbal medicines were included.The highest proportion of fresh drugs use was in internal medicine diseases(795 times,45.64％)and surgical diseases(346 times,19.86％).Conclusion Fresh medicine is widely used in the diagnosis and treatment of diseases in Qixiao Liangfang.Fresh medicine is mostly local medicinal materials with high representativeness and wide clinical applications,involving internal medcine and surgery,gynecology,pediatrics,dermatology,and otolaryngology,etc.It is not only used for common diseases,but also for various difficult and complicated diseases.Exploring relevant ancient literatures of fresh medicine provides reference for its modern clinical application.