Abstract： Introduction::Acrodermatitis continua of Hallopeau (ACH) is an uncommon chronic cutaneous disorder. Up to date, its treatment is still difficult and frustrating although various topical and systemic agents alone or in different combinations have been tried with variable benefits.Case presentation::Two cases of ACH were characterized by thumb involvement alone and showed an excellent response to calcipotriol/betamethasone ointment (1 g: calcipotriol 50 μg and betamethasone 0.5 mg).Discussion::Treatment of ACH is challenging for physicians. Multiple systemic therapies and topical drugs have been applied, however, no universally effective treatment regimen has yet been established for long-lasting remission. Combination of calcipotriol and betamethasone is more effective in treating psoriasis than the individual components alone, and the current 2 cases with ACH were reported to be treated successfully by the calcipotriol/betamethasone ointment.Conclusion::Topical calcipotriol/betamethasone compound is an optional agent for the treatment of ACH with a novel effect.