Abstract： Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common urological disease.In the research progress of CP/CPPS treatment,it has been found that the regulation of oxidative stress and inflammation response through nuclear factor kappa-B (NF-κB),nuclear factor erythroid-2 related factor 2 (Nrf2),mitogen-activated protein kinase (MAPK) and other signaling pathways can reduce CP/CPPS symptoms.In recent years,it has been found that the regulation of forkhead box O (FOXO),silent information regulator 1(Sirt1),extracellular signal-regulated kinase(Erk),ras homolog gene family member A(RhoA)/Rho-associated protein kinase 1(ROCK1) and other signaling pathways can relieve prostatic inflammation and pelvic pain,providing a new target for CP/CPPS treatment.