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本文报道1例继发性前列腺伯基特淋巴瘤患者，39岁，因无明显诱因出现排尿不畅伴尿频/尿急入院。全腹CT平扫检查示前列腺不规则软组织肿块，累及膀胱、直肠，并发双肾盂、输尿管轻度梗阻积水。行前列腺肿物穿刺活检，病理检查结果符合伯基特淋巴瘤。PET-CT检查示全身多处病灶和淋巴结肿大，诊断为继发性前列腺淋巴瘤。确诊后予利妥昔单抗＋依托泊苷＋长春地辛＋表柔比星＋环磷酰胺＋地塞米松方案化疗。患者治疗6个月，泌尿系症状缓解，排尿通畅。随访9个月，患者出现颅内转移，生命体征平稳。前列腺淋巴瘤罕见，需结合临床表现和实验室检查明确原发性还是继发性，要与前列腺炎、低分化前列腺癌等鉴别。

A case of secondary Burkitt lymphoma of prostate was reported. A 39-year-old patient was admitted to the hospital with no apparent cause for impaired urination with frequent/urgent urination. CT scan of the whole abdomen showed irregular soft tissue mass of the prostate, involving the bladder and rectum, and mild obstructive hydronephrosis of the renal pelvis and ureter. Biopsy of the prostatic mass was performed, and the pathological findings were consistent with Burkitt lymphoma. PET-CT examination showed multiple lesions and lymph node enlargement throughout the body, secondary prostate lymphoma was diagnosed. After diagnosis, the patient was treated with R-DA-EPOCH chemotherapy and followed up for 9 months. Prostate lymphoma is rare and needs to be combined with clinical manifestations and laboratory tests to determine whether it is primary or secondary, but also to distinguish from prostate diseases such as prostatitis and poorly differentiated prostate cancer.